The U.S. Fish and Wildlife Service and its partner, Point Blue Conservation Science, are proposing to restore the native ecosystem of the South Farallon Islands by removing non-native, invasive house mice and eliminating their negative impacts on the wildlife and wild habitats of the islands. The ecosystem is severely out of balance, putting the survival of threatened species and the unique habitat at risk, and the presence of invasive house mice have harmful direct and indirect impacts on the islands’ breeding seabirds. Removing invasive house mice will allow the ecosystem of the globally important Farallon Islands National Wildlife Refuge to recover from past human impacts, restoring the island to a more natural state that will also build resilience to the impacts of climate change.